Titre du document / Document title

Dietary ω-3 and ω-9 fatty acids uniquely enhance allograft survival in cyclosporine-treated and donor-specific transfusion-treated rats

Auteur(s) / Author(s)

ALEXANDER J. W. ⁽¹⁾ ; VALENTE J. F. ⁽¹⁾ ; GREENBERG N. A. ⁽²⁾ ; CUSTER D. A. ⁽¹⁾ ; OGLE C. K. ⁽¹⁾ ; GIBSON S. W. ⁽¹⁾ ; BABCOCK G. F. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Surgery, University Medical Center, Cincinnati, Ohio 5267-0558, ETATS-UNIS
⁽²⁾ Novartis Nutrition Technical Center, St. Louis Park, Minnesota 55416, ETATS-UNIS

Résumé / Abstract

Background. Both laboratory and clinical studies have shown that dietary lipids may affect immunologic responses. This study was conducted to compare different classes of long-chain unsaturated fatty acids for their effect on allograft survival in animals receiving a donor-specific transfusion and a short course of low-dose cyclosporine (CsA). Methods. Heterotopic ACI strain cardiac allografts were transplanted to Lewis strain rat recipients given diets with different lipid composition. In experiment 1, animals received CsA for 14 days and different diets were enriched with lipids with high concentrations of ω-3, ω-6, or ω-9 fatty acids. In experiment 2, animals received CsA for only 8 days and different diets were enriched with corn oil (ω-6), canola oil (ω-3 and ω-9), fish oil (ω-3) or a mixture of sunflower oil and fish oil (ω-3 and ω-9). Results. In experiment 1, animals receiving the diet with 30% sunflower oil had the best allograft survival (200±42 days vs. 53±8 days for regular chow plus donor-specific transfusion and CsA, P<0.05). In experiment 2, diets containing canola oil (a mixture of ω-3 and ω-9 fatty acids) were associated with the best survival (P=0.0011 vs. regular chow). Conclusion. Dietary ω-3 and ω-9 fatty acids both enhanced cardiac allograft survival in a stringent rat strain combination. Canola oil is a convenient oil for administering both α-linoleic acid (ω-3) and oleic acid (ω-9) in a palatable form for human consumption. Further investigation of the potential usefulness of lipids in transplant therapy is warranted.

Revue / Journal Title

Transplantation ISSN 0041-1337 CODEN TRPLAU

Source / Source

1998, vol. 65, n^o10, pp. 1304-1309 (33 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott, Hagerstown, MD, ETATS-UNIS (1963) (Revue)

Mots-clés anglais / English Keywords

Homotransplantation ; Heart ; Ciclosporin ; Low dose ; n-3 fatty acid ; Fish oil ; Linoleic acid ; Canola oil ; Supplemented diet ; Oleic acid ; Complication ; Treatment ; Diet therapy ; Prevention ; Rat ; Animal ; Chemotherapy ; Prognosis ; Immunosuppressive agent ; Survival ; Adjuvant treatment ; Rodentia ; Mammalia ; Vertebrata ; Transplantation ; Surgery ;

Mots-clés français / French Keywords

Homotransplantation ; Coeur ; Ciclosporine ; Dose faible ; Acide gras n-3 ; Huile poisson ; Linoléique acide ; Huile colza double zéro ; Régime alimentaire enrichi ; Oléique acide ; Complication ; Traitement ; Traitement diététique ; Prévention ; Rat ; Animal ; Chimiothérapie ; Pronostic ; Immunodépresseur ; Survie ; Traitement adjuvant ; Rodentia ; Mammalia ; Vertebrata ; Transplantation ; Chirurgie ;

Mots-clés espagnols / Spanish Keywords

Homotrasplante ; Corazón ; Ciclosporina ; Dosis débil ; Acido graso n-3 ; Aceite pescado ; Linoleico ácido ; Aceite canola ; Régimen alimenticio enriquecido ; Oleico ácido ; Complicación ; Tratamiento ; Tratamiento dietético ; Prevención ; Rata ; Animal ; Quimioterapia ; Pronóstico ; Inmunodepresor ; Sobrevivencia ; Tratamiento adyuvante ; Rodentia ; Mammalia ; Vertebrata ; Trasplantación ; Cirugía ;

Localisation / Location

INIST-CNRS, Cote INIST : 8318, 35400007565295.0040